Look at alternant therapies that are not average CYP3A inducers through cure with mitapivat. If not able to stay away from coadministration, check Hb and titrate beyond 50 mg BID, if essential, but do not exceed mitapivat dose of a hundred mg BID. .pentobarbital will lessen the extent or impact of dapsone by impacting hepatic/intestinal enzyme CYP3